Bioactive Small Molecules
TARGETMOL CHEMICALS INC CPPHA 25MG
Also available in 5 mg 10 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. CPPHA a positive allosteric modulator of glutamate receptors mGluR5 and mGluR1 is commonly used in development for central nervous system diseases. purity: 99%
Cayman Chemical ANTIBODY DonpezIl 25mg
An AChE inhibitor (IC50 = 6.7 nM); selective for AChE over BChE (IC50 = 988 nM); inhibits AβO1-42-induced NO and TNF-α production in primary rat microglial cells at 0.1 and 1 µM); increases ACh levels in the cortex and hippocampus of aged rats at 1.5 mg/kg; reduces Mac-1 and GFAP protein expression in hippocampal dentate gyrus of an AβO1-42-induced mouse model of Alzheimer’s disease at 2 mg/kg; increases step-through latency in a passive avoidance test in the same model
Cayman Chemical JNJ-37822681hydrochlorIde 25mg
A dopamine D2L receptor antagonist (Ki = 0.158 µM); selective for dopamine D2L receptors over dopamine D1 and D3, α1-adrenergic, and histamine H1 receptors, and the 5-HT receptor subtypes 5-HT2A and 5-HT2C in radioligand binding assays (Kis = >3, 1.159, >5, 4.931, 2.896, and >4 µM, respectively); inhibits apomorphine-induced stereotypy and D-amphetamine-induced hyperlocomotion in rat models of psychosis (ED50s = 0.19 and 1 mg/kg, respectively)
Cayman Chemical ANTIBODY Atovaquon 50mg
An antiprotozoal agent; inhibits complex III activity on dihydroorotate in isolated P. falciparum and P. yoelii mitochondria more potently than in rat liver mitochondria (EC50s = 0.95, 0.94, and 510 nM, respectively); depolarizes the mitochondrial membrane in P. yoelii-infected mouse erythrocytes (EC50 = 260 nM); inhibits human BCRP- and P-glycoprotein-mediated transport in membrane vesicles (IC50s = 0.23 and 6.8 μM, respectively); inhibits the growth of T. gondii in MRC-5 human lung fibroblasts in vitro (IC50 = ~64 nM); increases mean survival of T. gondii-infected mice from 5.5 to 21.2 days (100 mg/kg per day)
Cayman Chemical ANTIBODY PLX647 5mg
A dual inhibitor of FMS and KIT (IC50s = 28 and 16 nM, respectively); is selective for FMS and KIT but does inhibit FLT3 and KDR (IC50s = 91 and 130 nM, respectively) in a panel of 400 kinases at 1 μM; inhibits proliferation of Ba/F3 cells expressing constitutively active FMS or KIT (IC50s = 92 and 180 nM, respectively) as well as ligand-dependent growth of M-NFS-60 and M-07e cells (IC50s = 380 and 230 nM, respectively); reduces TNF-α and IL-6 release in a rat model of LPS-induced cytokine release at 40 mg/kg; reduces mast cell degranulation in a mouse model of PCA; inhibits bone destruction and delays disease progression in a mouse model of CIA; reverses bone osteolysis and allodynia in a syngeneic rat model of cancer-induced bone pain
Medchemexpress LLC DBCO-(PEG)3-VC-PAB-MMAE | 2754384-60-4 | 99.6% | 1613.97 | 100 MG
DBCO-(PEG)3-VC-PAB-MMAE is an agent-linker conjugate for ADC, formed by conjugating Monomethyl auristatin E to a DBCO-(PEG)3-vc-PAB linker. It is intended for cancer research and functions as a click chemistry reagent, utilizing a DBCO group for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.
- Agent-linker conjugate for ADC
- Made by Monomethyl auristatin E conjugated to a DBCO-(PEG)3-vc-PAB linker
- Click chemistry reagent
- Contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups
- Can be used for the research of cancer
Medchemexpress LLC Dehydroascorbic acid (Standard) | 490-83-5 | 99.8% | 174.11 | 50 MG
Dehydroascorbic acid (Standard) is the analytical standard of Dehydroascorbic acid. This product is intended for research and analytical applications. Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke.
- Qualitative research experiments in HPLC, GC and MS.
- Quantitative research experiments in HPLC, GC and MS.
- Methodological research experiments in HPLC, GC and MS.
Medchemexpress LLC GW-803430 | 515141-51-2 | 99.1% | 481.99 | 500 UG
GW-803430 (GW-3430) is a potent and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pIC50 of 9.3. It is orally active in an animal model of obesity. For research use only.
- Potent and selective melanin-concentrating hormone receptor 1 antagonist.
- Orally active in animal models of obesity.
Selleck Chemical LLC FSLLRY-NH2 TFA S9915-25MG
FSLLRY-NH2 TFA (FSY-NH2) is a selective protease-activated receptor 2 (PAR2) inhibitor with an ic50 of 50 M in PAR2-KNRK cells
Selleck Chemical LLC BMS-986158 S9691-10MM/1ML
BMS-986158 is a potent inhibitor of BET with IC50s of 6 6 nM and 5 nM in NCI-H211 small cell lung cancer (SCLC) cells and MDA-MB231 triple negative breast cancer (TNBC) cells respectively
Selleck Chemical LLC 4-HNE S9793-100MG
4-HNE (4-Hydroxynonenal) is one of the major end products of lipid peroxidation and has been widely accepted as an inducer of oxidative stress
Selleck Chemical LLC JC-1 S9784-5MG
JC-1 (CBIC2 NK 1420) a fluorescent lipophilic carbocyanine dye is a mitochondrial potential ( (m)) marker JC-1 fluorescence is usually excited by the 488 nm laser wavelength common in flow cytometers
Selleck Chemical LLC Penbutolol Sulfate S9470-5MG
Penbutolol sulfate ((-)-Terbuclomine) is an effective beta-adrenergic receptor blocker and diuretic that is used as an antihypertensive agent
Selleck Chemical LLC Eriodictyol S9123-5MG
Eriodictyol a flavonoid extracted from yerba santa has anti-inflammatory and antioxidant activities and taste-modifying properties
Selleck Chemical LLC Isoliensinine S9247-1MG
Isoliensinine is an alkaloid produced by the edible plant Nelumbo nucifera It possesses anti-cancer anti-fibrosis anti-proliferative antioxidant and anti-inflammatory activities